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KMID : 1101420160480030217
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Korean Journal of Clinical Laboratory Science
2016 Volume.48 No. 3 p.217 ~ p.224
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An Analysis of the Antibiotic Resistance Genes of Multi-Drug Resistant (MDR) Acinetobacter baumannii
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Lim Ji-Na
Lee Gyu-Sang
Choi Yeon-Im
Kim Jong-Bae
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Abstract
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Acinetobacter baumannii (A. baumannii) is prevalent in hospital environments and is an important opportunistic pathogen of nosocomial infection. It is known that this pathogen cause herd infection in hospitals, and the mortality rate is remarkably higher for patients infected with this pathogen and already have other underlying diseases. Herein, we investigated the antibiotic resistance rate and the type of resistance genes in 85 isolates of multi-drug resistant A. baumannii from the samples commissioned to laboratory medicine in two university hospitals?in hospital A and hospital B?located in Cheonan and Chungcheong provinces, respectively, in Korea. As a result, blaOXA-23-like and blaOXA-51-like were detected in 82 stains (96.5%). These 82 strains of blaOXA-23-like producing A. baumannii were confirmed with the ISAba1 gene found at the top of the blaOXA-23-like genes by PCR, inducing the resistance against carbapenemase. The armA, AME gene that induces the resistance against aminoglycoside was detected in 34 strains out of 38 strains from Hospital A (89.5%), and in 40 strains out of 47 strains from Hospital B (85.1%), while AMEs were found in 33 strains out of 38 strains from Hospital A (70.2%) and in 44 strains out of 47 strains in Hospital B (93.6%). Therefore, it was found that most multi-drug resistant A. baumannii from the Cheonan area expressed both acethyltransferase and adenyltransferase. This study investigated the multi-drug resistant A. baumannii isolated from Cheonan and Chungcheong provinces in Korea, and it is thought that the results of the study can be utilized as the basic information to cure multi-drug resistant A. baumannii infections and to prevent the spread of drug resistance.
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KEYWORD
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Multi-drug resistant Acinetobacter baumannii, Carbapenemase, ISAbaI, armA, Aminoglycoside-modifying enzyme
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